Dependence and addiction are signalized by obsessive use of specific drugs. This is based on the fact that permanent use of these drugs changes the milieu. Specific micro-organisms for which these drugs do not harm or are even good for them, find their place in our organism as they have an advantage over others (and our immune defence). We could identify these micro-organisms and develop a specific CITERA™  therapy reducing the urge of taking alcoholic beverages massively.